Renal Tubular Transport #16. S1 Segment, Proximal Tubule. Organic Anion Transport 1

in hive-163521 •  4 months ago 

Picture Steemit Renal Tubular Transport.jpg

This post is showing the organic anion transport.

  • The Na/K ATPase, which brings 2 potassium ions into the cell and releases 3 sodium ions into the interstitial space.
  • The sodium/dicarboxylate cotransporter (NaDC1) at the apical membrane, which brings in 3 sodium ions from the filtrate together with 1 dicarboxylate ion which could be citrate, α keto-glutarate or succinate.
  • The sodium/dicarboxylate cotransporter (NaDC3) at the basolateral membrane, which brings in 3 sodium ions from the interstitium and brings in mainly α keto-glutarate. This transporter is important for the organic anion transport which will be shown at a later post.
  • The sodium/monocarboxylate cotransporter (SMTC2) at the apical membrane, which brings in 2 sodium ions from the filtrate together with 1 monocarboxylate ion such as lactate.
  • In the basolateral membrane, the α keto-glutarate brought in by NaDC3 is exchanged again so than an organic anion can be brought in from the interstitial space.
  • In the apical membrane, OAT4 and URAT1, bring in urate so that organic anions can be released into the filtrate. OAT4 focuses more in dicarboxylates and URAT1 in monocarboxylates and chlorine.
  • Organic anions can be metabolites of endogenous or exogenous compounds, with a negative charge.

Picture Steemit Tubular Cell Transport Organic Anion 1.jpg

Previous Posts in this Series
Renal Tubular Transport #1. S1 Segment, Proximal Tubule. Sodium Transport 1 (Sodium/Hydrogen Ion Transport) (2nd Edition)
Renal Tubular Transport #2. S1 Segment, Proximal Tubule. Sodium Transport 2 (Sodium/Phosphate Transport) (2nd Edition)
Renal Tubular Transport #3. S1 Segment, Proximal Tubule. Sodium Transport 3
Renal Tubular Transport #4. S1 Segment, Proximal Tubule. Sodium Transport 4
Renal Tubular Transport #5. S1 Segment, Proximal Tubule. Sodium Transport 5
Renal Tubular Transport #6. S1 Segment, Proximal Tubule. Sodium Transport 6
Renal Tubular Transport #7. S1 Segment, Proximal Tubule. Sodium Transport 7
Renal Tubular Transport #8. S1 Segment, Proximal Tubule. Sodium Transport 8
Renal Tubular Transport #9. S1 Segment, Proximal Tubule. Potassium Transport 1
Renal Tubular Transport #10. S1 Segment, Proximal Tubule. Potassium Transport 2
Renal Tubular Transport #11. S1 Segment, Proximal Tubule. Calcium Transport 1
Renal Tubular Transport #12. S1 Segment, Proximal Tubule. Water Transport 1
Renal Tubular Transport #13. S1 Segment, Proximal Tubule. Magnesium Transport 1
Renal Tubular Transport #14. S1 Segment, Proximal Tubule. Glucose Transport 1
Renal Tubular Transport #15. S1 Segment, Proximal Tubule. Phosphate Transport 1
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