This post is showing the organic anion transport.
- The Na/K ATPase, which brings 2 potassium ions into the cell and releases 3 sodium ions into the interstitial space.
- The sodium/dicarboxylate cotransporter (NaDC1) at the apical membrane, which brings in 3 sodium ions from the filtrate together with 1 dicarboxylate ion which could be citrate, α keto-glutarate or succinate.
- The sodium/dicarboxylate cotransporter (NaDC3) at the basolateral membrane, which brings in 3 sodium ions from the interstitium and brings in mainly α keto-glutarate. This transporter is important for the organic anion transport which will be shown at a later post.
- The sodium/monocarboxylate cotransporter (SMTC2) at the apical membrane, which brings in 2 sodium ions from the filtrate together with 1 monocarboxylate ion such as lactate.
- In the basolateral membrane, the α keto-glutarate brought in by NaDC3 is exchanged again so than an organic anion can be brought in from the interstitial space.
- In the apical membrane, OAT4 and URAT1, bring in urate so that organic anions can be released into the filtrate. OAT4 focuses more in dicarboxylates and URAT1 in monocarboxylates and chlorine.
- Organic anions can be metabolites of endogenous or exogenous compounds, with a negative charge.